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W.M. Keck Foundation

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Medical Research
2008
Recipient  Buck Institute
City  Novato, CA
Description  To research the role of the aging process in the etiology of human disease.

Recipient  Northwestern University
City  Evanston, IL
Description  To examine whether zinc plays a central role in oocyte maturation and in mediating early signals in embryogenesis.

Recipient  Stanford University
City  Stanford, CA
Description  To support research using bioengineering technologies to study electrically excitable tissue in rodent models of neuropsychiatric, motor, and cardiac disease.

2007
Recipient  City of Hope
City  Los Angeles, CA
Description  To continue work to understand the molecular mechanisms underlying cancer and develop therapies that destroy lymphoma cells without harming normal cells.

Recipient  Arizona State University
City  Tempe, AZ
Description  To study frameshift peptides common in tumors as targets for development of a cancer vaccine.

Recipient  Carnegie Mellon University
City  Pittsburgh, PA
Description  To research how the brain composes neural representations of word and sentence meanings from their component parts.

Recipient  Stanford University
City  Stanford, CA
Description  To develop equipment to study the structure and dynamics of neural circuits.

Recipient  Translational Genomics Research Institute
City  Phoenix, AZ
Description  To develop network models of biological function using signal processing and control theory.

Recipient  University of California, Los Angeles
City  Los Angeles, CA
Description  To develop stem cell technology to engineer human immune cells for targeted cancer treatments.

Recipient  University of California, San Francisco
City  San Francisco, CA
Description  To characterize and understand the function of the non-protein coding RNA genes by developing new mouse models for human disease.

Recipient  University of Massachusetts Medical School
City  Worcester, MA
Description  To study how asymmetric cell division affects aging and longevity in somatic and stem cells.

Recipient  University of Oregon
City  Eugene, OR
Description  To study biological interactions of engineered nanoparticles and establish fundamental design rules for biomedical applications.

Recipient  University of Texas - M. D. Anderson Cancer Center
City  Houston, TX
Description  To understand molecular mechanisms behind the generation of immunosuppressive T-cells in the thymus and tumor microenvironment and to develop cancer immunotherapies.

2006
Recipient  City of Hope
City  Los Angeles, CA
Description  To understand the molecular mechanisms underlying cancer and develop new therapies that destroy lymphoma cells without harming normal cells.

Recipient  Cold Spring Harbor Laboratory
City  Cold Spring Harbor, NY
Description  To map the architecture of the human and rodent brain and gain an insight into neural dynamics underlying motivated behavior.

Recipient  Indiana University-Purdue University Indianapolis
City  Indianapolis, IN
Description  To understand the mechanisms of regeneration and restoration in amphibians and apply these mechanisms in potential therapies for spinal cord injury patients.

Recipient  Mount Sinai School of Medicine
City  New York, NY
Description  To study the pandemic risk of avian influenza viruses using an animal model of human transmission.

Recipient  University of California, Berkeley
City  Berkeley, CA
Description  To establish a laboratory to research structures and functions of the fundamental molecular machines that mediate information flow in cells and viruses.

Recipient  University of Louisville
City  Louisville, KY
Description  To study the cellular and molecular mechanisms of facilitating-cell regulatory function on hematopoetic stem cells.

Recipient  University of Michigan
City  Ann Arbor, MI
Description  To develop an integrated system of distributed microscale actuators, intracellular sensors and feedback controls capable of chemically interfacing with a developing embryo.

Recipient  University of Pennsylvania
City  Philadelphia, PA
Description  To develop novel methods for understanding the cell types involved in neurodegenerative diseases like Parkinson's, and develop therapeutic interventions.

Recipient  Washington State University
City  Pullman, WA
Description  To gain insight into the mechanisms underlying the phenomenon of sleep.

Recipient  Yale University
City  New Haven, CT
Description  To map basic cellular networks in the brain and the immune system.

2005
Recipient  Dana-Farber Cancer Institute
City  Boston, MA
Description  To support the Human Interactome Project, which will provide insight into the networks of physical interactions among cellular proteins.

Recipient  Oregon Health & Science University
City  Portland, OR
Description  To equip the Advanced Imaging Research Center with a 11.75T animal MR imaging and spectroscopy system and develop high-resolution, high-sensitivity brain imaging methodologies.

Recipient  Oregon State University
City  Corvallis, OR
Description  To build an electron capture dissociation chamber to improve fragmentation of peptides and therefore data obtained from mass spectrometry.

Recipient  Tufts University
City  Medford, MA
Description  To purchase instrumentation required for the study of complex interrelationships between the human immune system and its disease-causing pathogens.

Recipient  University of California, San Diego
City  La Jolla, CA
Description  For a tri-institutional collaboration to analyze human stem cell differentiation pathways using extremely rapid robotic screening techniques.

Recipient  University of California, Santa Barbara
City  Santa Barbara, CA
Description  To define the role of specific microRNAs in the establishment and maintenance of neuronal identity.

Recipient  University of New Mexico
City  Albuquerque, NM
Description  To study a newly identified class of steroid receptors that are highly expressed in tumors, which will advance the development of new and more effective cancer treatments.

2004
Recipient  George Washington University
City  Washington, DC
Description  To combine a MALDI mass spectrometer with a scanning near-field optical microscope to obtain images of protein distribution in living cells and tissues.

Recipient  Jackson Laboratory
City  Bar Harbor, ME
Description  For research into gene function and expression at the cellular and subcellular levels using a new generation of confocal microscopy techniques.

Recipient  Memorial Sloan-Kettering Cancer Center
City  New York, NY
Description  To explore the molecular and cellular mechanisms of cancer metastasis using imaging methods and molecular biology techniques.

Recipient  Tulane University
City  New Orleans, LA
Description  To develop adult stem cells for research use, and specifically to study the molecular mechanisms used by stem cells to repair tissue damage.

Recipient  University of Wisconsin, Madison
City  Madison, WI
Description  To study the biological mechanisms that cause undifferentiated embryonic stem cells to develop into cells with highly specific functions.

Recipient  Washington University in St. Louis
City  St. Louis, MO
Description  To explore how the microbial community that inhabits the gut influences nutrition, immunity, cancer risks and other aspects of human health.

Medical Research Special Grant

Recipient  Doheny Eye Institute
City  Los Angeles, CA
Description  To support the intraocular retinal prosthesis program.

2003
Recipient  Colorado State University
City  Fort Collins, CO
Description  To support research that will explore the role of chromatin structure in controlling gene expression.

Recipient  Morehouse School of Medicine
City  Atlanta, GA
Description  To study the genes and proteins involved in neuronal regeneration and neurodegenerative disorders.

Recipient  Neurosciences Institute
City  San Diego, CA
Description  To study the neural bases of perception, cognition, and behavior using a synthetic neural modeling system.

Recipient  University of California, Los Angeles
City  Los Angeles, CA
Description  For a collaborative project to understand, diagnose and treat epithelial cancers using nanotechnology methods.

Recipient  University of Colorado at Boulder
City  Boulder, CO
Description  To develop a facility to study single molecules of RNA, and for bioinformatics research to predict RNA structure and function.

Recipient  University of Illinois at Urbana-Champaign
City  Champaign, IL
Description  To study molecules critical to nervous system development and to understand mechanisms for repairing damaged neuronal circuits.

Recipient  University of Texas Medical Branch at Galveston
City  Galveston, TX
Description  To equip a virus imaging center in a biosafety level-3 laboratory for studying infectious diseases like West Nile and SARS.

Recipient  Western Michigan University
City  Kalamazoo, MI
Description  To measure line tension, a force essential to the transport of materials into and out of cell membranes.

2002
Recipient  Fred Hutchinson Cancer Research Center
City  Seattle, WA
Description  To support the development of proteomic technology for an early identification of human susceptibility to cancers and other diseases.

Recipient  Mayo Foundation
City  Rochester, MN
Description  To construct a highly sensitive mass spectrometer for protein analysis to aid early identification of disease or determine changes in proteins that contribute to disease.

Recipient  University of California, Riverside
City  Riverside, CA
Description  To purchase proteomics instruments for the Genomics Institute to study functional genetics in key plants, insects, and pathogens that are important for protecting the world's food supply.

Recipient  University of Michigan
City  Ann Arbor, MI
Description  To use nanoprobes for detection of rare ionic events in cells and model how these essential minerals are involved in health and disease.

Recipient  University of Minnesota, Twin Cities
City  Minneapolis, MN
Description  To purchase a 9.4 Tesla/65cm MRI for the Center for Magnetic Resonance Research to develop ultra-high field methodologies for non-invasive longitudinal studies of the brains of humans and primates.

2001
Recipient  Baylor College of Medicine
City  Houston, TX
Description  To establish the Gulf Coast Consortium in Magnetic Resonance, combining the research strengths in computational and structural biology of six Houston-area universities and expanding existing training programs at the Keck Center for Computational Biology.

Recipient  Duke University
City  Durham, NC
Description  To establish the W. M. Keck Center for Neuro-oncology Genomics that will apply new genomic, proteomic and bioinformatic technologies to characterize brain tumors and develop therapies targeted to specific tumors.

Recipient  Johns Hopkins University
City  Baltimore, MD
Description  To establish the Center for the Rational Design of Biologically Active Molecules in the School of Medicine, which will facilitate synthetic organic chemistry approaches to biomedical problems.

Recipient  Medical University of South Carolina
City  Charleston, SC
Description  To continue support for the Sea Islands Families Project, specifically to support the community-based efforts involved in the development of this unique genetic resource.

Recipient  New York Structural Biology Center
City  New York, NY
Description  To purchase a 900 MHz NMR system for high-resolution studies of macromolecular structures for a consortium of ten institutions in the New York area.

Recipient  University of California, San Francisco
City  San Francisco, CA
Description  To support the establishment of laboratory for the study of cellular function and to develop new imaging technologies for atomic- to cellular-level resolution.

Recipient  University of Colorado Health Sciences Center
City  Denver, CO
Description  To purchase an 800 MHz NMR to be shared by UCHSC, UC Boulder and the University of Utah and establish the Keck Advanced High-Field NMR Center of the Rocky Mountain Region.

Recipient  University of Iowa
City  Iowa City, IA
Description  To establish a multidisciplinary project in Microbial Communities and Cell Signaling conducted in collaboration with the Kewalo Marine Laboratory at the University of Hawaii.

Recipient  University of Washington
City  Seattle, WA
Description  To support the Center for Functional, Structural and Chemical Genomics of Microbial Pathogens, which will apply new technologies to the worldwide problem of microbial pathogenicity.





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